Chapter 349 Do you have anything else to ask

Doctor’s Life Simulator Chapter 349 What else do you want to ask?

“Okay, Professor Liu, after I clean up, I will go directly to the Second Hospital of Harbin Medical University.”

Qin Lang’s expression remained unchanged, and he very shyly agreed to Professor Liu’s invitation:

“Professor Liu, we’ll see you tomorrow, it doesn’t matter if you have money or not, and I don’t care about reputation. The main thing is to be able to participate in such a meaningful second heart transplant, and to have the opportunity to be with the leading figure in the field of heart transplantation. Professor Liu It is an honor for me to collaborate.”

Hearing Qin Lang’s words, Director Dong on the side also twitched at the corner of his mouth. This Director Qin’s face is as top-notch as his skills.

“That’s great, Director Qin, we’ll see you tomorrow. I’ll arrange the doctor to be in charge of the reception right away.”

Professor Liu communicated with Director Dong for a while and cut off the video communication.

“Director Chen, Director Qin’s pick-up and accommodation and living matters will be left to you. Be sure to entertain them.”

Professor Liu looked at Chen Minjie and said something.

“Guaranteed to complete the mission.”

Director Chen forced a smile on his face, but blood was dripping in his heart. This chance to help was originally his.

And Qin Lang exchanged with Director Dong at Xiehe Hospital again, and rushed back to the hotel directly.

As soon as I walked into the aisle, I saw a girl sneaking half-squatting at the door of her room, holding a small card from her hand and stuffing it.

“Hey you!”

Qin Lang shouted, and the girl turned her head immediately and saw the tall and big Qin Lang, her face flushed red.

Immediately got up, thought about it, covered his face with one hand, and ran away.

“Stop, what are you doing?”

Qin Lang couldn’t help but ask.

The girl stuffed the small card in her pocket, swallowed her saliva, looked at the handsome Qin Lang, and struggled: “Begging for a son with a lot of money, yes, begging for a son with a lot of money, my sister has been paying attention to you for a long time because you are so handsome. I’m not that little card.”

The girl emphasized again, for fear of Qin Lang’s misunderstanding, she ran errands.

Qin Lang touched his face, but he was also very helpless. Sure enough, boys should learn to protect themselves when they are outside.

Qin Lang opened the door of the room, and just as he was about to go in, his phone vibrated, and he took it out and looked at it. It was Director Dong who paid him the surgery fee. When he looked at it, it turned out to be a total of 200,000 yuan!

Then there was a text message from Director Dong: “Director Qin, the total cost of this operation is 300,000 yuan. Since you are involved in a lot of operations, you have the bulk. As the nominal chief surgeon, I will share 100,000 yuan. Happy cooperation and looking forward to the next one. cooperation.”

For this, Qin Lang is also very satisfied. Director Dong is very particular. Under normal circumstances, even if the chief surgeon is named, at least half of it will be distributed.

Qin Lang thought about it for a while, but he didn’t seem to know what to say. Following the principle of less talk and less mistakes, he replied directly: “Okay.”

Director Dong, who received the text message, also chuckled lightly, this Director Qin is really a master.

When Qin Lang was about to start packing and rushing to the Second Hospital of Harbin Medical University, the phone rang again.

“What’s the matter?”

Qin Lang took out his mobile phone. It was Wang Rou, a former doctoral student of Professor Shen Xi, who is now the head of his new company’s pharmaceutical research and development laboratory.

This time Qin Lang entrusted her with the research and development of smoking cessation drugs, so when she saw Wang Rou’s phone call, Qin Lang was also full of expectations.

I only heard Dr. Wang Rou’s excited voice on the phone:

“Director Qin, good news. According to your previous arrangements, after the completion of the first-phase compound synthesis, our second-phase experiment is also on the right track. It’s just that a key problem has arisen now, and I urgently need you to come back and fix it. Check it out. If it goes well, we will be able to enter Phase III clinical trials within a few months, and will be able to conduct regulatory approvals soon.”

Hearing Wang Rou’s news, Qin Lang was also quite satisfied. Sure enough, after having the simulation of the new drug research and development simulation laboratory, and then projecting it into reality, the experiment was really smooth.

Qin Lang is also convinced that as long as the next clinical trials follow his guidance, there will be no problems with the new drug.

Qin Lang thought about it, he could wait until he went to Harbin Medical University to complete the operation before returning to Hangzhou, and arranged in a calm tone:

“Okay, I know Dr. Wang. You have all worked hard recently. I have a very important consultation and an operation in the past two days. I will come back when it is completed.”

Hearing Qin Lang’s indifference, Wang Rou was a little anxious. Why is the operation so important?

“Director Qin, do you know what it means to pass the third phase of clinical trials! That is a domestic market of billions each year, and billions of overseas markets. If the new drug is successful and passes the regulatory approval, we will Posted!”

Wang Rou really couldn’t understand, Director Qin was so sullen, she shouldn’t rush back at such a time, and what kind of surgery was going on.

“Director Qin, our current experiment has reached a critical stage. If you don’t come back to check, we will lose all our efforts in this period of time.”

Qin Lang thought for a while about Wang Rou’s request. Anyway, he had everything under control, so he would go back and guide him, it wouldn’t take much time.

As for the second hospital of Harbin Medical University, the last general consultation before the operation is still needed, and there is still some time for the formal operation. After that, you can conduct the consultation remotely yourself.

After making a plan, Qin Lang took out his mobile phone and booked a flight back to Hangzhou to see what problems Wang Rou’s team encountered.

Under normal circumstances, drug development is very difficult, and the process of drug development is extremely complex.

Taking Ming’s Pharmaceutical Group’s drug research and development as an example, from early research and development to drug launch, the steps and processes to go through are so long that they can be arranged from A to H.

A, the first is basic research. This process starts with patient, clinicopathological, and statistical data to find and validate potential targets.

Under normal circumstances, this step would take several years of efforts by developers, but in Qinlang, it was completed directly.

B, Pharmacology and biomarker development. Including target pharmacology and druggability research, biomarker research related to target and prognosis.

This step was skipped by Qin Lang. Under normal circumstances, at least tens of millions of dollars would be invested in the laboratory of Ming’s Pharmaceutical Group, and it would even take several years to complete it.

C, Lead compound discovery. Lead compounds are compounds with a certain biological activity obtained by various ways and means, usually obtained by in vitro screening for further structural modification and optimization.

This step, if it is in the laboratory of Ming’s Pharmaceutical Group, also needs to spend tens of millions of dollars, and the R&D personnel need some luck to find it. And this step, Qin Lang also completed in an instant.

D, Lead compound optimization, preclinical candidate compound confirmation, preclinical research, manufacturing and quality control (CMC) in support of the declaration. In this link, potential drug candidate molecules are screened, and systematic pharmacodynamic and toxicological studies are carried out. It is also necessary to produce samples to support clinical research under good quality management (GMP) conditions.

In this step, for Ming’s Pharmaceutical Group, two or three of the dozens of drug research and development projects can enter this step, which is already considered very lucky.

Often, at this stage, hundreds of millions of R&D expenses have been spent, and it has gone through several years.

Therefore, for the researchers of the drug laboratory, Qin Lang’s smoking cessation drug project, the compound synthesis of bupropion was completed not long after, and the small sample of reagents made them astonished.

The more I understand the difficulty of new drug research and development, the more I understand how difficult it is for Qin Lang to get to this point.

Wang Rou greeted Qin Lang with great admiration.

“Director Qin, you really only spent a few months designing this prototype of bupropion?”

Dr. Wang still asked in disbelief. At first, she felt that this project was far away. When she saw the demo, she was completely stunned.

Without even relying on the team strength of Ming’s Pharmaceutical Group, only relying on her own team, she has successfully synthesized the lead compound. Such a smooth and bizarre research and development process is unheard of even among all the new drug research and development projects she knows about. .

Hearing Qin Lang’s confirmation, Wang Rou looked at Qin Lang as if she were looking at an immortal.

“It’s really the man who is the **** of medicine, Chu Gu.”

Wang Rou led Qin Lang: “Director Qin, after you have provided the lead compound, we have officially entered clinical research.”

Namely: E, Clinical studies. It mainly conducts clinical trials, including Phase I, Phase II and Phase III clinical trials. Each phase has a different goal and a different scale.

Wang Rou took Qin Lang to see the first phase of the clinical trial they had completed.

“Director Qin, you see, the first phase of the clinical trial is mainly for the preliminary clinical pharmacology and human safety evaluation experiments. The laboratory has completed the human body’s tolerance and pharmacokinetics of the new drug. Provide evidence.”

“Under your guidance in the early stage, we greatly reduced the range of drug doses, and quickly obtained the relationship between drug doses and drug side effects. At the same time, we also clarified the dynamic properties of drugs and The firmness of metabolites, and how the drug is metabolized in the human body.”

“The end result is exactly what you predicted.”

Wang Rou looked at Qin Lang in disbelief, as if the man in front of him had traveled back from the future and possessed the ability to predict.

“After that, we went straight to Phase II clinical trials.”

Wang Rou, continue to show Qin Lang the data and various materials of the team’s clinical trials during this period.

Because of the simulation in the system’s laboratory, Qin Lang is very clear about this information and knows the correct data.

“Gene Era”

Therefore, there is no need for Wang Rou’s detailed explanation, and even in some summary statistical results, Qin Lang is clearer than Dr. Wang.

After all, Wang Rou relies on the lab staff to sort out and count the experimental data to get the final result.

And Qin Lang is the standard answer to read directly, and there will always be some deviations in the artificial statistics of the laboratory.

“Director Qin, the Phase II clinical trial is the preliminary evaluation stage of the therapeutic effect, and its purpose is to preliminarily evaluate the therapeutic effect and safety of the drug on patients with the target indications. In this step, the design and administration of the Phase III clinical trial also need to be determined. Dosage plan. This time, I invite you to come here because I want to work out the plan for this three-phase experiment together.”

“Here is my preliminary plan and data support, you can take a look first.”

Wang Rou herself has a lot of research on statistics and data processing. After all, his second major is mathematics, especially statistics.

Seeing Wang Rou’s data and formula, Qin Lang is also very impressed. Wang Rou’s formula is very close to the standard answer.

Qin Lang looked at it and said with admiration: “Dr. Wang’s foundation is really solid. This plan is basically feasible. In this way, give me a day tomorrow, and I will give you my advice.”

“certainly.”

Wang Rou replied with great anticipation, and brought Qin Lang to his general manager’s office.

In the laboratory, the rest of the members are also very curious and looking forward to how amazing this Director Qin is!

After a day of retreat, studying the experimental data, and proposing a plan for the third phase, just listening to it will make the blood of the laboratory personnel boil. If they can really come to a conclusion, then this Director Qin will really make them worship.

The next day, Qin Lang was in the office, of course, just to hide people’s eyes and ears. After all, it was too scary to give an answer at a glance.

Moreover, Qin Lang took advantage of this time to participate in the consultation of the Second Hospital of Harbin Medical University through the remote system, as long as the operation was rushed to the scene afterwards.

The general meeting of the department is originally an exchange of thinking and ideas, and there is no need to be present in person.

In the general manager’s office of Qin Lang, there are various supporting facilities, and naturally there is no shortage of remote systems.

This new company, Ming’s Pharmaceutical Group, has invested a lot of money, and it is naturally very advanced, especially Qin Lang’s office, which is spacious and atmospheric.

Qin Lang put away a pile of materials and wrote down the dosage plan for the third phase and the clinical trial plan for the third phase.

First, several sets of Wang Rou’s data were revised, and then a randomized blind selection method was used to control the clinical trial, and the placebo and marketed drugs were added as a control.

Soon, a rigorous scientific and detailed plan was completed.

After doing all this, Qin Lang checked the time and arrived at the consultation time of the Second Hospital of Harbin Medical University.

At this moment, in the consultation room of the Second Hospital of Harbin Medical University, the expert group also broke out.

“Is this Director Qin reliable or not? Didn’t he say he came to the consultation today, what about people?”

“Director Qin, I didn’t get on that flight at all. I waited at the airport for a long time and didn’t arrive, and I didn’t get through on the phone.”

Physician Chen’s face was full of grievances, but he was a little happy in his heart. If Qin Lang really didn’t come, the first help would be his.

Professor Liu also did not expect that Director Qin had escaped from the battle.

Just when he was depressed, the phone rang, it was Qin Lang’s number, and Professor Liu immediately connected.

“Professor Liu, I’m sorry, I’m in the same situation as you in Xiehe Hospital before. I also have an emergency here. I was supposed to go to the Second Hospital of Harbin Medical University this morning, but there are some problems with my new drug research and development project. I’m in the guidance laboratory. The plan for conducting Phase III clinical trials. Therefore, today we can only participate in the consultation through remote video.”

Professor Liu also did not expect Director Qin to be so difficult to deal with.

Moreover, he even led the research and development of a new drug, and also conducted a Phase III clinical trial?

What a magical operation.

Professor Liu smiled bitterly: “Okay, then I’ll arrange a remote video.”

Professor Liu hung up the phone and said that after Qin Lang wanted to participate in the consultation via remote video, the expert group exploded one by one.

“This is too arrogant, no one comes, direct video consultation?”

“That’s right, we don’t take us seriously.”

“Gui Caixin, a young doctor like him can lead the research and development of new drugs, and he has also entered the third phase of clinical trials.”

“Is it because I’m not confident about my participation in the second heart transplant, so I simply didn’t dare to come over. I found a reason during the consultation to shirk it.”

“It’s very possible, after all, the difficulty and complexity of a normal heart transplant and a second heart transplant are worlds apart.”

“Hey, I lost the chain at a critical moment. I really looked up to him before.”

For a while, the expert group had a lot of discussions about Qin Lang’s remote video consultation, and they were not optimistic.

“Okay, all be quiet. Director Qin was invited by me, and I will be responsible for all his actions. After a normal consultation, I will connect Director Qin’s video link in, and everyone will be treated as a regular alliance of experts from other hospitals. consultation.”

Professor Liu, as the person in charge of this operation, since he has spoken, the doctors of the expert group will not speak anymore.

However, there is always some resistance in my heart. After all, Qin Lang is too young. For such a young doctor, he doesn’t even come to the scene, and the video consultation is a little contempt for them.

Before the consultation started, Professor Liu also pondered for a while, and said to Chen Minjie: “In a while, you will be in charge of Director Qin’s video connection. If Director Qin really can’t come over in time after the consultation, the operation will be over. It’s up to you to cooperate with me.”

“Hey, okay.”

A trace of joy flashed in Chen Minjie’s eyes, but his face was still very calm: “Professor Liu, rest assured, I will definitely cooperate with Director Qin, and I am also ready to rise at any time.”

“Well, let’s go.”

Professor Liu looked at Chen Minjie and was slightly relieved, but he also hoped that Qin Lang would come to the Second Hospital of Harbin Medical University. After all, Chen Minjie’s level is still far from Qin Lang’s. .

Commonly known as the jack, even the spare tire is not as good as the kind.

In the independent office of the new company, Qin Lang opened the remote video on time and joined the Second Hospital of Harbin Medical University. The third general consultation on Ye Jian’s second heart transplant was also the last consultation before the operation.

Qin Lang saw the situation in the consultation room very clearly through the screen.

The entire consultation was presided over by Professor Liu. Before the meeting, Professor Liu first introduced Qin Lang, who participated in the remote consultation, to the expert group.

Regarding the greeting on Qin Lang’s screen, the expert group smiled politely, but did not look at him.

Under the control of Professor Liu, the consultation began.

In the content of the meeting, Professor Liu first summed up the content of the previous two consultations, and then Director Chen reported the progress of the latest equipment, instruments and special drugs.

“Professor Liu, with the cooperation of various departments in our hospital, all the equipment and medicines required for Ye Jian’s surgery have been prepared.”

After that, each department reported their latest progress one by one. Overall, everything was ready.

Ten minutes later, Professor Liu began to enter the second part of the consultation, that is, the most critical pre-operation study, the allocation of intraoperative personnel and the role each person needs to play.

As a candidate who is valued by Professor Liu, Qin Lang has to take on a huge responsibility.

Although I had seen Qin Lang’s surgery before, but after all, it was a routine heart transplant operation, and this time, Qin Lang chose a video consultation with some big names, and some doctors in the expert group were a little unhappy.

One of the chief physicians asked politely:

“Director Qin, as the one-to-one assistant in this operation is very important. Just in time for this consultation, we also want to know what Director Qin’s understanding of Ye Jian’s second heart transplant operation is.”

On the screen, Qin Lang didn’t care about the aggressiveness of the expert group at all. After all, in the simulated world, with his master-level heart transplantation, he could easily deal with any tricky problems.

Qin Lang smiled slightly, if he could help these doctors, he would be very happy.

He said very honestly: “Experts, I am still very confident about this technique.”

During the consultation room, Professor Liu also looked at Qin Lang unexpectedly. This young doctor is really not low-key at all.

“Then let’s start with the preparation of the receptor. How does Director Qin think about the preparation of the receptor?”

A chief physician looked up at the screen and said coldly.

Qin Lang didn’t even think about it, and responded very easily:

“In addition to a comprehensive medical history before surgery, a detailed physical examination should be carried out, including routine blood, urine, and stool routines; blood biochemistry, liver and kidney function, lung function, gastrointestinal barium fluoroscopy, throat swab, sputum, urine Bacterial culture. Tuberculin test, serum E-cell inclusion body virus, toxoplasma, HIV, EB virus and hepatitis virus examination. Blood type identification, lymphocyte toxicity cross-test and typing are also required…especially for the leaves In this case, for patients with severe heart failure that cannot be controlled by drugs, intra-aortic balloon counterpulsation should be performed, or the application of mechanical assist devices should be considered to temporarily improve the function of their organs and create conditions for heart transplantation…”

Hearing Qin Lang’s eloquent talk, the director nodded, and was horrified.

These questions, this Qin Lang was not prepared at all, and answered them all improvised, that is to say, he really has a deep understanding of heart transplantation.

In the consultation room, Chen Minjie was also a little unbelievable. Of course, he could answer these questions, but as comprehensive and rigorous as Qin Lang, he still needed to do his homework in advance.

“Good solid basic skills.”

Originally, I wanted to wait for Qin Lang to get stuck, and then educate the members of the expert team who need humility to do things for others, and they all suffocated.

Such a tough little guy.

The director of another urology department next to him couldn’t sit still. He was just watching a play. Now he had to save face for the doctor of the Second Hospital of Harbin Medical University, and asked another question:

“Director Qin has really done a lot of research on heart transplantation, and the preparation of this recipient is very comprehensive. Then, what does Director Qin think about the use of donor hearts?”

Since the heart donation requires the cooperation of multi-disciplinary organ physicians and the cooperation of urologists on the same stage, it is a very comprehensive process. When asking this question, I want to suppress Qin Lang’s momentum and let him know. This is a very comprehensive operation, and the ability of the individual is very limited.

Regarding this question, Qin Lang frowned slightly, and no matter how stupid he was, he could feel the targeting of these experts from thousands of miles away.

Qin Lang chuckled lightly, but he was not afraid. Since he wanted to test himself, he would take this opportunity to show it off and convince all these experts.

This will also help with subsequent surgery.

After arranging his sleeves, Qin Lang looked at the director of the Department of Urology with sharp eyes, and replied in a daze:

“I’m really familiar with donation heart collection. If you have any questions about donation heart collection surgery, you can ask me~www.readmtl.com~ I’ll answer your questions.”

“What a big breath.”

The medical consultation is like this, it is easy to exchange anger in the exchange.

Of course, more are academic **** for tat.

“Excuse me, how does Director Qin deal with thrombosis in the small blood vessels of the donor heart?”

One of the chief physicians was the first to ask questions. He really couldn’t stand it any longer. Qin Lang was like an old expert.

“Very simple, take a supine position, routinely disinfect the skin of the chest and abdomen with iodine tincture, and heparinize the whole body at 3mg/kg…”

Another chief physician flipped through the information and asked, “How does Director Qin ensure that the cardiac arrest is in a diastolic state, and how to design the perfusion volume and perfusion pressure?”

“Ensure that the donor cardiac arrest is in the diastolic state, the perfusion volume is generally 1000ml, and the perfusion pressure is maintained at 40-80mmHg.”

Qin Lang’s expression did not change, his expression did not change, and he returned very calmly.

“Then Director Qin, how to prevent the heart from dilating when the cardioplegia is infused?”

One of the chief physicians asked about a very detailed operation. If you are not familiar with this technique, you will definitely get stuck.

Qin Lang didn’t stop at all, and said smoothly:

“The right upper pulmonary vein and inferior vena cava should be incised immediately when the cardioplegic solution is started to prevent the heart from distending, and at the same time, ice saline should be placed in the pericardial cavity for local cooling…”

…

…

Twenty minutes later, Qin Lang looked at the panel of experts with sweat on their foreheads, and Feng Danyun asked lightly:

“What else do you want to ask?”+Bookmark+